Levosimendan pharmacokinetics
نویسندگان
چکیده
منابع مشابه
Hemodynamic Effects and Pharmacokinetics of Levosimendan and Its Metabolites in Patients with Severe Heart Failure
Levosimendan is a new drug for the treatment of decompensated heart failure. In previous studies, levosimendan has been shown to increase cardiac contractility through myofilament calcium sensitisation and induce peripheral and coronary vasodilation by opening ATP-sensitive potassium channels. The elimination half-life of levosimendan is approximately one hour in man. Preclinical studies have s...
متن کاملLevosimendan and organic protection
The use of levosimendan has not only improved the outlook of patients with pump failure, limiting itself to be a good inotropic: it also had as results the extension of its use to the organ protection realm. Numerous articles have been published of levosimendan (the (-) enantiomer of {(4(1,4,5,6-tetrahydro-4-methyl-6-oxo-3pyridazinyl) phenyl) hydrazono} propanedinitrile), referring to its molec...
متن کاملLevosimendan in acute myocardial infarction
Introduction: Levosimendan, a calcium sensitizer and opener of ATP-dependent potassium channels, has positive inotropic, vasodilatory, and cardioprotective properties. Method: 28 patients with acute myocardial infarction and/or cardiogenic shock (50%) scheduled for emergency surgical revascularization were treated with levosimendan in addition to catecholamines. Results: 21 (75%) patients survi...
متن کاملLevosimendan for post-partum cardiomyopathy.
OBJECTIVE To describe the use of levosimendan, a novel inotropic agent, for the treatment of post-partum cardiomyopathy (PPCMO). METHODS The authors present the second recorded use of levosimendan for a woman with PPCMO. RESULTS Levosimendan improved cardiac performance which was associated with symptomatic relief and echocardiographic improvement in ventricular function. The patient recove...
متن کاملCan we believe in levosimendan?
Mailing address: Ferenc Follath • Steering Group for Drug Therapy University Hospital, Office HAL 16/18, D2 Raemistr. 100, CH 8091 Zürich – Switzerland E-mail: [email protected] Acute cardiac decompensation in patients with a pre-existing chronic heart failure is frequent, but its optimal management remains a controversial issue. Treatment depends on the precipitating cause, such as myocard...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2010
ISSN: 1663-9812
DOI: 10.3389/conf.fphar.2010.60.00109